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HelpTest Code LAB9869 Glycosaminoglycan Analysis, Urine
Aliases
GAG
Urinary GAG Screen
MPS TLC
Performing Section
Biochemical Genetics
Specimen Type
Urine:
Sterile Container
Specimen Volume
Preferred: 1.0 mL
Minimum: 0.5 mL
Processing Instructions
Store and ship sample frozen on dry ice.
TAT
7 days
CPT
84375
Special Collection Notes
May squeeze from cotton balls placed in diaper.
Purpose/Principle
In this method urinary GAGs are first digested using a series of hydrolases. The resulting disaccharides are separated and quantified using stable isotopically labeled internal standards and LCMS/MS. Analytical measurements are adjusted for creatinine concentration and are compared to age related normal ranges.
Temperature
Frozen (dry ice)
Test Components
Dermatan Sulfate
Heparan Sulfate
Keratan Sulfate
Glycosaminoglycan, Urine Qualitative
Reference Range
Dermatan Sulfate0 up to 6 Months: 0.0-20.1 mcg/mg creatinine
6 Months up to 12 Months: 0.0-13.6 mcg/mg creatinine
12 Months up to 3 Years: 0.0-13.9 mcg/mg creatinine
3 Years up to 7 Years: 0.0-3.8 mcg/mg creatinine
7 Years up to 14 Years: 0.0-4.6 mcg/mg creatinine
14 Years and up: 0.0-2.6 mcg/mg creatinine
Heparan Sulfate
0 up to 6 Months: 0.0-24.5 mcg/mg creatinine
6 Months up to 12 Months: 0.0-11.9 mcg/mg creatinine
12 Months up to 3 Years: 0.0-9.9 mcg/mg creatinine
3 Years up to 7 Years: 0.0-5.6 mcg/mg creatinine
7 Years up to 14 Years: 0.0-6.9 mcg/mg creatinine
14 Years and up: 0.0-3.0 mcg/mg creatinine
Keratan Sulfate
0 up to 6 Months: 0.0-16.4 mcg/mg creatinine
6 Months up to 12 Months: 0.0-4.9 mcg/mg creatinine
12 Months up to 3 Years: 0.0-4.2 mcg/mg creatinine
3 Years up to 7 Years: 0.0-3.9 mcg/mg creatinine
7 Years up to 14 Years: 0.0-1.7 mcg/mg creatinine
14 Years and up: 0.0-0.8 mcg/mg creatinine
Glycosaminoglycan, Urine Qualitative
Normal