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HelpTest Code LAB9869 Glycosaminoglycan Analysis, Urine
Aliases
GAG
Urinary GAG Screen
MPS TLC
Performing Section
Biochemical Genetics
Purpose/Principle
In this method urinary GAGs are first digested using a series of hydrolases. The resulting disaccharides are separated and quantified using stable isotopically labeled internal standards and LCMS/MS. Analytical measurements are adjusted for creatinine concentration and are compared to age related normal ranges.
Special Collection Notes
May squeeze from cotton balls placed in diaper.
Specimen Type
Urine:
Sterile Container
Specimen Volume
Preferred: 1.0 mL
Minimum: 0.5 mL
Processing Instructions
Store and ship sample frozen on dry ice.
Temperature
Frozen (dry ice)
TAT
7 days
Test Components
Dermatan Sulfate
Heparan Sulfate
Keratan Sulfate
Glycosaminoglycan, Urine Qualitative
CPT
84375
Reference Range
Dermatan Sulfate0 up to 6 Months: 0.0-20.1 mcg/mg creatinine
6 Months up to 12 Months: 0.0-13.6 mcg/mg creatinine
12 Months up to 3 Years: 0.0-13.9 mcg/mg creatinine
3 Years up to 7 Years: 0.0-3.8 mcg/mg creatinine
7 Years up to 14 Years: 0.0-4.6 mcg/mg creatinine
14 Years and up: 0.0-2.6 mcg/mg creatinine
Heparan Sulfate
0 up to 6 Months: 0.0-24.5 mcg/mg creatinine
6 Months up to 12 Months: 0.0-11.9 mcg/mg creatinine
12 Months up to 3 Years: 0.0-9.9 mcg/mg creatinine
3 Years up to 7 Years: 0.0-5.6 mcg/mg creatinine
7 Years up to 14 Years: 0.0-6.9 mcg/mg creatinine
14 Years and up: 0.0-3.0 mcg/mg creatinine
Keratan Sulfate
0 up to 6 Months: 0.0-16.4 mcg/mg creatinine
6 Months up to 12 Months: 0.0-4.9 mcg/mg creatinine
12 Months up to 3 Years: 0.0-4.2 mcg/mg creatinine
3 Years up to 7 Years: 0.0-3.9 mcg/mg creatinine
7 Years up to 14 Years: 0.0-1.7 mcg/mg creatinine
14 Years and up: 0.0-0.8 mcg/mg creatinine
Glycosaminoglycan, Urine Qualitative
Normal