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Test Code LAB9745 Porphyrins, Feces

Additional Codes

FQPPS

Reporting Name

Porphyrins, F

Useful For

Evaluation of patients who present with signs or symptoms suggestive of porphyria cutanea tarda, hereditary coproporphyria, variegate porphyria, congenital erythropoietic porphyria, erythropoietic protoporphyria, or X-linked dominant protoporphyria

Testing Algorithm

The following algorithms are available:

-Porphyria (Acute) Testing Algorithm

-Porphyria (Cutaneous) Testing Algorithm

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type

Fecal


Necessary Information


1. Weight of the non-homogenized sample

2. Collection duration

3. Include a list of medications the patient is currently taking.

4. Indicate if patient was compliant with the patient preparation requirements.



Specimen Required


Patient Preparation:

1. For 3 days before collection and during the entire specimen collection period, patient must refrain from eating red meat and or taking any aspirin-containing medications.

2. Patient should not use barium, laxatives, or enemas for 24 hours before starting, as well as during, specimen collection.

Collection Container/Tube: Stool Containers - 24, 48, 72 Hour Kit (T291). No preservative.

Specimen Volume: Entire collection (48, 72, or 96 hour). 24-Hour collection is adequate if the collection volume is at least 100 g

Collection Instructions:

1. Collect all stool specimens within a 24, 48, 72, or 96 hour timeframe.

2. Do not add preservative.

3. Send entire collection.

Additional Information:

1. Length of collection period is required.

2. Specimens smaller than 100 g may not provide accurate results.

3. Include a list of medications the patient is currently taking.


Specimen Minimum Volume

See Specimen Required

Specimen Stability Information

Specimen Type Temperature Time Special Container
Fecal Frozen (preferred) 14 days
  Refrigerated  14 days

Reference Values

UroporphyrinI:

<120 mcg/24 h

 

Uroporphyrin III:

<50 mcg/24 h

 

Heptacarboxyl porphyrin I:

<40 mcg/24 h

 

Heptacarboxyl porphyrin III:

<40 mcg/24 hours

 

Isoheptacarboxyl porphyrins:

<30 mcg/24 h

 

Hexacarboxnyl porphyrin:

<10 mcg/24 h

 

Hexacarboxnyl porphyrin III:

<10 mcg/24 h

 

Isohexacarboxnyl porphyrins :

<10 mcg/24 h

 

Pentacarboxyl porphyrin I:

<20 mcg/24 hours

 

Pentacarboxyl porphyrin II:

<20 mcg/24 h

 

Isopentacarboxyl porphyrins:

<80 mcg/24 hours

 

Coproporphyrin I:

<500 mcg/24 h

 

Coproporphyrin III:

<400 mcg/24 h

 

Isocoproporphyrin:

<200 mcg/24 h

 

Protoporphyrins:

<1,500 mcg/24 h

 

Coproporphyrin III/Coproporphyrin I RATIO:

<1.20

 

See The Heme Biosynthetic Pathway

Day(s) Performed

Tuesday, Thursday

CPT Code Information

84126

Report Available

3 to 7 days

Reject Due To

Specimens in preservative Reject
 

Method Name

High-Performance Liquid Chromatography (HPLC)