Sign in →

Test Code LAB9075 Comprehensive Solid Tumor (DNA and RNA analysis)

Performing Section

PRECISION DIAGNOSTICS

Purpose/Principle

This panel includes DNA and RNA analysis of 185 genes that have been described in the diagnosis, prognosis, or treatment decision process for a variety of solid tumors. This panel was created with a focus on pediatric solid tumors but may be clinically relevant for a variety of adult neoplasms as well.

Special Collection Notes

Collect specimen according to standard operating procedure.

Specimen Type

Whole Blood/Bone Marrow : Purple Top Tube-EDTA

 

Mouth: Buccal Swab

 

Tissue (Fresh-Frozen, Paraffin Embedded, or RPMI)

Specimen Volume

Whole Blood/Bone Marrow

Preferred: 4.0 mL

Minimum: 0.5 mL

*Receipt of blood or bone marrow within 72 hours of collection. Delays may impact nucleic acid quality.

 

Tissue

Preferred: uncut paraffin-embedded tissue block. Slides: 1 stained and 10 unstained - 10 micron thick slides

*Receipt within 24 hours of cutting or as soon as possible. Delays may impact nucleic acid quality.

Processing Instructions

Store and ship ambient. If transport is longer than 4 hours send refrigerated on cold pack.
For frozen tissue please send on dry ice- ASAP.

Temperature

Ambient/Refrigerated

Test Components

DNA Gene content:
AKT1, AKT2, AKT3, ALK, AMER1, APC, ARAF, ARID1A, ARID1B, ARID2, ATM, ATR, ATRX, AURKA, AURKB, AXIN1, B2M, BCL2, BCL6, BCOR, BCORL1, BRAF, BRCA1, BRCA2, BRD4, BRIP1, CCND1, CCND2, CCND3, CD274, CDK4, CDK6, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CHEK2, CIC, CREBBP, CTNNB1, DAXX, DDR2, DDX3X, DICER1, DLG2, EED, EGFR, EP300, ERBB2, ERBB3, ERG, ESR1, ETV6, EZH2, FGFR1, FGFR2, FGFR3, FGFR4, FLCN, FUBP1, GLI2, GNA11, GNAQ, GNAS, GPC3, H3F3A, H3F3B, hist1H1C, HIST1H3B, HRAS, IDH1, IDH2, IGF1R, IRS1, JAK1, JAK2, JAK3, JUN, KDM5A, KDM5C, KDM6A, KDR, KIT, KMT2A, KMT2C, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAP3K3, MAPK1, MDM2, MDM4, MECOM, MEN1, MET, MLH1, MSH2, MSH6, MTOR, MYB, MYBL1, MYC, MYCN, MYOD1, NF1, NF2, NOTCH1, NOTCH2, NRAS, NTRK1, NTRK2, NTRK3, PAX5, PDCD1, PDGFRA, PDGFRB, PHOX2B, PIK3CA, PIK3CB, PIK3CG, PIK3R1, PIK3R2, PMS2, POLE, PPM1D, PTCH1, PTEN, PTPN11, PTPRD, RAF1, RB1, RET, RICTOR, ROS1, RPTOR, SDHA, SDHB, SDHC, SDHD, SETD2, SMAD2, SMAD4, SMARCA4, SMARCB1, SMO, SRC, STAG2, STAT3, STK11, SUFU, SUZ12, TERC, TERT, TGFBR2, TP53, TP63, TSC1, TSC2, VHL, WT1, XPO1

RNA Gene content:
ABI1, ABL1, ABL2, ACACA, ACE, ACER1, ACKR3, ACSL6, ACTB, ADD3, AFF1, AFF3, AFF4, AGR3, AHI1, AHRR, ALK, ANKRD28, AR, ARHGAP20, ARHGAP26, ARNT, ASPSCR1, ASTN2, ATF1, ATIC, ATP1B4, AUTS2, AXL, BACH2, BAG4, BAIAP2L1, BAZ2A, BCAS3, BCAS4, BCL10, BCL11A, BCL11B, BCL2, BCL2L1, BCL3, BCL6, BCL9, BCOR, BCR, BDNF, BICC1, BIRC3, BIRC6, BLNK, BRAF, BRD1, BRD3, BRD4, BRWD3, BTBD18, BTG1, C11orf1, C11orf95, C2CD2L, CAMTA1, CAPRIN1, CARS, CASC5, CASP7, CBFA2T3, CBFB, CBL, CCAR2, CCDC28A, CCDC6, CCDC88C, CCNB1IP1, CCNB3, CCND1, CCND2, CCND3, CD74, CDH11, CDK5RAP2, CDK6, CDX1, CDX2, CEBPA, CEBPB, CEBPD, CEBPE, CEP170B, CEP85L, CHD6, CHIC2, CHMP2B, CHST11, CIC, CIITA, CITED2, CLP1, CLTC, CLTCL1, CMKLR1, CNBP, CNOT2, CNTRL, COG5, COL1A1, COL1A2, COL6A3, COX6C, CPSF6, CRADD, CREB1, CREB3L1, CREB3L2, CREBBP, CRLF1, CRLF2, CRTC1, CSF1, CSF1R, CTDSP2, CTNNB1, CUX1, DAB2IP, DACH1, DACH2, DDIT3, DDX10, DDX20, DEK, DGKH, DMRT1, DNAJB1, DPM1, DUSP22, EBF1, EEFSEC, EGFR, EGR1, EGR2, EGR3, EGR4, EIF4A2, ELF4, ELK4, ELL, ELN, EML1, EML4, EP300, EP400, EPC1, EPOR, EPS15, ERBB2, ERBB3, ERC1, ERCC1, ERG, ERLIN2, ESR1, ETS1, ETV1, ETV4, ETV5, ETV6, EVL, EWSR1, EZR, FAM19A2, FCGR2B, FCRL4, FEN1, FEV, FGF8, FGFR1, FGFR1OP, FGFR1OP2, FGFR2, FGFR3, FGFR4, FGR, FHIT, FIP1L1, FLI1, FLNA, FLT3, FLT3LG, FNBP1, FOS, FOSB, FOSL1, FOXO1, FOXO4, FOXP1, FRK, FRYL, FUS, GAS7, GATA1, GIT2, GLI1, GLIS2, GOSR1, GOT1, GPR128, GPR34, GRHPR, GRID1, GRM1, GTF2I, H2AFX, HAS2, HEY1, HHEX, HIP1, HIPK1, HIST1H4I, HLF, HMGA2, HNF1A, HOXA10, HOXA11, HOXA13, HOXA9, HOXC11, HOXC13, HOXD11, HOXD13, HRAS, HSP90AA1, ID4, IKZF1, IKZF2, IKZF3, IL2, IL21R, IL2RB, IL3, INPP5D, INSR, IQCG, IRF2BP2, IRF4, IRS4, ITK, JAK1, JAK2, JAZF1, KANK1, KAT6A, KAT6B, KDM5A, KIAA1524, KIF5B, KMT2A, KMT2B, KMT2C, KMT2D, KPNB1, KRAS, KSR1, LASP1, LCK, LCP1, LGR5, LHFP, LHX2, LHX4, LMBRD1, LMO1, LMO2, LNP1, LPP, LPXN, LRMP, LRRC37B, LTBP1, LYL1, MACROD1, MAF, MAFB, MALT1, MAML2, MAN2B1, MAPRE1, MBNL1, MBTD1, MDS2, MEAF6, MECOM, MEF2D, MET, MGEA5, MKL1, MKL2, MLF1, MLLT1, MLLT10, MLLT11, MLLT3, MLLT4, MLLT6, MN1, MNX1, MSI2, MSN, MTCP1, MUC1, MUTYH, MYB, MYBL1, MYC, MYH11, MYH9, MYO18A, MYO1F, NAB2, NAPA, NBR1, NCOA1, NCOA2, NCOA3, NCOR1, NDE1, NF1, NFATC2, NFIB, NGF, NGFR, NIN, NIPBL, NKX2-1, NKX2-5, NONO, NOTCH1, NOTCH2, NPM1, NR4A3, NR6A1, NRAS, NRG1, NSD1, NT5C2, NTF3, NTF4, NTRK1, NTRK2, NTRK3, NUMA1, NUMBL, NUP107, NUP214, NUP98, NUTM1, NUTM2A, NUTM2B, OFD1, OLIG2, OLR1, OMD, P2RY8, PAPPA, PATZ1, PAX3, PAX5, PAX7, PAX8, PBX1, PCM1, PDE4DIP, PDGFB, PDGFRA, PDGFRB, PER1, PGR, PHF1, PHF23, PICALM, PIK3CA, PIM1, PKN1, PLAG1, PML, POM121, POU2AF1, POU5F1, PPAP2B, PPARG, PPARGC1A, PPFIBP1, PPP2R1B, PRCC, PRDM16, PRKACA, PRKAR1A, PRKCA, PRKCB, PRKG2, PRRX2, PSIP1, PSMD2, PTK2B, PTPRR, RABEP1, RAD51B, RAF1, RANBP2, RAP1GDS1, RARA, RBM15, RBM6, RCOR1, RCSD1, RELA, RET, RHOH, RNF213, ROS1, RPL22, RPN1, RREB1, RRM1, RSPO2, RSPO3, RTEL1, RUNX1, RUNX1T1, SARNP, SEC31A, SEPTIN2, SEPTIN5, SEPTIN6, SEPTIN9, SERPINE1, SERPINF1, SET, SETBP1, SFPQ, SH3D19, SH3GL1, SIK3, SLC34A2, SLC45A3, SLCO1B3, SMAP1, SMARCA5, SMARCB1, SNHG5, SORBS2, SORT1, SP3, SPECC1, SPTBN1, SQSTM1, SRF, SRSF3, SS18, SS18L1, SSBP2, SSX1, SSX2, SSX4, ST6GAL1, STAT5B, STAT6, STIL, STRN, SUFU, SUGP2, SUZ12, SYK, TACC1, TACC2, TACC3, TAF15, TAL1, TAL2, TAOK1, TBX15, TCF12, TCF3, TCL1A, TCTA, TEAD1, TEAD2, TEAD3, TEAD4, TEC, TENM1, TERT, TET1, TFE3, TFEB, TFG, TFPT, TFRC, TGFBR3, THADA, THRAP3, TIRAP, TLX1, TLX3, TMPRSS2, TNFRSF17, TOP1, TOP2B, TP53BP1, TP63, TP73, TPM3, TPM4, TRA, TRB, TRD, TRHDE, TRIM24, TRIP11, TRPS1, TSLP, TTYH1, TYK2, USP16, USP42, USP6, VGLL2, VGLL3, WASF2, WDR18, WDR70, WHSC1, WHSC1L1, WSB1, WT1, WWTR1, XIAP, YAP1, YTHDF2, YWHAE, ZBTB16, ZC3H7A, ZC3H7B, ZFP64, ZFPM2, ZFTA (c11orf95), ZFYVE19, ZMIZ1, ZMYM2, ZMYND11, ZNF207, ZNF384, ZNF444, ZNF521, ZNF585B, ZNF687

Reference Range

Result

No clinically significant variants identified

 

TMB, Classification

Baseline

 

TMB, Mutation Rate

This component has no reference ranges

 

TMB, Total Number of Variants

This component has no reference ranges

 

DNA Variant(s)

This component has no reference ranges

 

RNA Variant(s)

This component has no reference ranges

TAT

21 days

Aliases

Solid Comp
Solid Tumor NGS Panel

CPT

81455