Test Code LAB9075 Comprehensive Solid Tumor (DNA and RNA analysis)
Performing Section
PRECISION DIAGNOSTICS
Purpose/Principle
This panel includes DNA and RNA analysis of 185 genes that have been described in the diagnosis, prognosis, or treatment decision process for a variety of solid tumors. This panel was created with a focus on pediatric solid tumors but may be clinically relevant for a variety of adult neoplasms as well.
Special Collection Notes
Collect specimen according to standard operating procedure.
Specimen Type
Whole Blood/Bone Marrow : Purple Top Tube-EDTAMouth: Buccal Swab
Tissue (Fresh-Frozen, Paraffin Embedded, or RPMI)
Specimen Volume
Whole Blood/Bone Marrow
Preferred: 4.0 mL
Minimum: 0.5 mL
*Receipt of blood or bone marrow within 72 hours of collection. Delays may impact nucleic acid quality.
Tissue
Preferred: uncut paraffin-embedded tissue block. Slides: 1 stained and 10 unstained - 10 micron thick slides
*Receipt within 24 hours of cutting or as soon as possible. Delays may impact nucleic acid quality.
Processing Instructions
Store and ship ambient. If transport is longer than 4 hours send refrigerated on cold pack.
For frozen tissue please send on dry ice- ASAP.
Temperature
Ambient/Refrigerated
Test Components
DNA Gene content:
AKT1, AKT2, AKT3, ALK, AMER1, APC, ARAF, ARID1A, ARID1B, ARID2, ATM, ATR, ATRX, AURKA, AURKB, AXIN1, B2M, BCL2, BCL6, BCOR, BCORL1, BRAF, BRCA1, BRCA2, BRD4, BRIP1, CCND1, CCND2, CCND3, CD274, CDK4, CDK6, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CHEK2, CIC, CREBBP, CTNNB1, DAXX, DDR2, DDX3X, DICER1, DLG2, EED, EGFR, EP300, ERBB2, ERBB3, ERG, ESR1, ETV6, EZH2, FGFR1, FGFR2, FGFR3, FGFR4, FLCN, FUBP1, GLI2, GNA11, GNAQ, GNAS, GPC3, H3F3A, H3F3B, hist1H1C, HIST1H3B, HRAS, IDH1, IDH2, IGF1R, IRS1, JAK1, JAK2, JAK3, JUN, KDM5A, KDM5C, KDM6A, KDR, KIT, KMT2A, KMT2C, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAP3K3, MAPK1, MDM2, MDM4, MECOM, MEN1, MET, MLH1, MSH2, MSH6, MTOR, MYB, MYBL1, MYC, MYCN, MYOD1, NF1, NF2, NOTCH1, NOTCH2, NRAS, NTRK1, NTRK2, NTRK3, PAX5, PDCD1, PDGFRA, PDGFRB, PHOX2B, PIK3CA, PIK3CB, PIK3CG, PIK3R1, PIK3R2, PMS2, POLE, PPM1D, PTCH1, PTEN, PTPN11, PTPRD, RAF1, RB1, RET, RICTOR, ROS1, RPTOR, SDHA, SDHB, SDHC, SDHD, SETD2, SMAD2, SMAD4, SMARCA4, SMARCB1, SMO, SRC, STAG2, STAT3, STK11, SUFU, SUZ12, TERC, TERT, TGFBR2, TP53, TP63, TSC1, TSC2, VHL, WT1, XPO1
RNA Gene content:
ABI1, ABL1, ABL2, ACACA, ACE, ACER1, ACKR3, ACSL6, ACTB, ADD3, AFF1, AFF3, AFF4, AGR3, AHI1, AHRR, ALK, ANKRD28, AR, ARHGAP20, ARHGAP26, ARNT, ASPSCR1, ASTN2, ATF1, ATIC, ATP1B4, AUTS2, AXL, BACH2, BAG4, BAIAP2L1, BAZ2A, BCAS3, BCAS4, BCL10, BCL11A, BCL11B, BCL2, BCL2L1, BCL3, BCL6, BCL9, BCOR, BCR, BDNF, BICC1, BIRC3, BIRC6, BLNK, BRAF, BRD1, BRD3, BRD4, BRWD3, BTBD18, BTG1, C11orf1, C11orf95, C2CD2L, CAMTA1, CAPRIN1, CARS, CASC5, CASP7, CBFA2T3, CBFB, CBL, CCAR2, CCDC28A, CCDC6, CCDC88C, CCNB1IP1, CCNB3, CCND1, CCND2, CCND3, CD74, CDH11, CDK5RAP2, CDK6, CDX1, CDX2, CEBPA, CEBPB, CEBPD, CEBPE, CEP170B, CEP85L, CHD6, CHIC2, CHMP2B, CHST11, CIC, CIITA, CITED2, CLP1, CLTC, CLTCL1, CMKLR1, CNBP, CNOT2, CNTRL, COG5, COL1A1, COL1A2, COL6A3, COX6C, CPSF6, CRADD, CREB1, CREB3L1, CREB3L2, CREBBP, CRLF1, CRLF2, CRTC1, CSF1, CSF1R, CTDSP2, CTNNB1, CUX1, DAB2IP, DACH1, DACH2, DDIT3, DDX10, DDX20, DEK, DGKH, DMRT1, DNAJB1, DPM1, DUSP22, EBF1, EEFSEC, EGFR, EGR1, EGR2, EGR3, EGR4, EIF4A2, ELF4, ELK4, ELL, ELN, EML1, EML4, EP300, EP400, EPC1, EPOR, EPS15, ERBB2, ERBB3, ERC1, ERCC1, ERG, ERLIN2, ESR1, ETS1, ETV1, ETV4, ETV5, ETV6, EVL, EWSR1, EZR, FAM19A2, FCGR2B, FCRL4, FEN1, FEV, FGF8, FGFR1, FGFR1OP, FGFR1OP2, FGFR2, FGFR3, FGFR4, FGR, FHIT, FIP1L1, FLI1, FLNA, FLT3, FLT3LG, FNBP1, FOS, FOSB, FOSL1, FOXO1, FOXO4, FOXP1, FRK, FRYL, FUS, GAS7, GATA1, GIT2, GLI1, GLIS2, GOSR1, GOT1, GPR128, GPR34, GRHPR, GRID1, GRM1, GTF2I, H2AFX, HAS2, HEY1, HHEX, HIP1, HIPK1, HIST1H4I, HLF, HMGA2, HNF1A, HOXA10, HOXA11, HOXA13, HOXA9, HOXC11, HOXC13, HOXD11, HOXD13, HRAS, HSP90AA1, ID4, IKZF1, IKZF2, IKZF3, IL2, IL21R, IL2RB, IL3, INPP5D, INSR, IQCG, IRF2BP2, IRF4, IRS4, ITK, JAK1, JAK2, JAZF1, KANK1, KAT6A, KAT6B, KDM5A, KIAA1524, KIF5B, KMT2A, KMT2B, KMT2C, KMT2D, KPNB1, KRAS, KSR1, LASP1, LCK, LCP1, LGR5, LHFP, LHX2, LHX4, LMBRD1, LMO1, LMO2, LNP1, LPP, LPXN, LRMP, LRRC37B, LTBP1, LYL1, MACROD1, MAF, MAFB, MALT1, MAML2, MAN2B1, MAPRE1, MBNL1, MBTD1, MDS2, MEAF6, MECOM, MEF2D, MET, MGEA5, MKL1, MKL2, MLF1, MLLT1, MLLT10, MLLT11, MLLT3, MLLT4, MLLT6, MN1, MNX1, MSI2, MSN, MTCP1, MUC1, MUTYH, MYB, MYBL1, MYC, MYH11, MYH9, MYO18A, MYO1F, NAB2, NAPA, NBR1, NCOA1, NCOA2, NCOA3, NCOR1, NDE1, NF1, NFATC2, NFIB, NGF, NGFR, NIN, NIPBL, NKX2-1, NKX2-5, NONO, NOTCH1, NOTCH2, NPM1, NR4A3, NR6A1, NRAS, NRG1, NSD1, NT5C2, NTF3, NTF4, NTRK1, NTRK2, NTRK3, NUMA1, NUMBL, NUP107, NUP214, NUP98, NUTM1, NUTM2A, NUTM2B, OFD1, OLIG2, OLR1, OMD, P2RY8, PAPPA, PATZ1, PAX3, PAX5, PAX7, PAX8, PBX1, PCM1, PDE4DIP, PDGFB, PDGFRA, PDGFRB, PER1, PGR, PHF1, PHF23, PICALM, PIK3CA, PIM1, PKN1, PLAG1, PML, POM121, POU2AF1, POU5F1, PPAP2B, PPARG, PPARGC1A, PPFIBP1, PPP2R1B, PRCC, PRDM16, PRKACA, PRKAR1A, PRKCA, PRKCB, PRKG2, PRRX2, PSIP1, PSMD2, PTK2B, PTPRR, RABEP1, RAD51B, RAF1, RANBP2, RAP1GDS1, RARA, RBM15, RBM6, RCOR1, RCSD1, RELA, RET, RHOH, RNF213, ROS1, RPL22, RPN1, RREB1, RRM1, RSPO2, RSPO3, RTEL1, RUNX1, RUNX1T1, SARNP, SEC31A, SEPTIN2, SEPTIN5, SEPTIN6, SEPTIN9, SERPINE1, SERPINF1, SET, SETBP1, SFPQ, SH3D19, SH3GL1, SIK3, SLC34A2, SLC45A3, SLCO1B3, SMAP1, SMARCA5, SMARCB1, SNHG5, SORBS2, SORT1, SP3, SPECC1, SPTBN1, SQSTM1, SRF, SRSF3, SS18, SS18L1, SSBP2, SSX1, SSX2, SSX4, ST6GAL1, STAT5B, STAT6, STIL, STRN, SUFU, SUGP2, SUZ12, SYK, TACC1, TACC2, TACC3, TAF15, TAL1, TAL2, TAOK1, TBX15, TCF12, TCF3, TCL1A, TCTA, TEAD1, TEAD2, TEAD3, TEAD4, TEC, TENM1, TERT, TET1, TFE3, TFEB, TFG, TFPT, TFRC, TGFBR3, THADA, THRAP3, TIRAP, TLX1, TLX3, TMPRSS2, TNFRSF17, TOP1, TOP2B, TP53BP1, TP63, TP73, TPM3, TPM4, TRA, TRB, TRD, TRHDE, TRIM24, TRIP11, TRPS1, TSLP, TTYH1, TYK2, USP16, USP42, USP6, VGLL2, VGLL3, WASF2, WDR18, WDR70, WHSC1, WHSC1L1, WSB1, WT1, WWTR1, XIAP, YAP1, YTHDF2, YWHAE, ZBTB16, ZC3H7A, ZC3H7B, ZFP64, ZFPM2, ZFTA (c11orf95), ZFYVE19, ZMIZ1, ZMYM2, ZMYND11, ZNF207, ZNF384, ZNF444, ZNF521, ZNF585B, ZNF687
Reference Range
ResultNo clinically significant variants identified
TMB, Classification
Baseline
TMB, Mutation Rate
This component has no reference ranges
TMB, Total Number of Variants
This component has no reference ranges
DNA Variant(s)
This component has no reference ranges
RNA Variant(s)
This component has no reference ranges
TAT
21 days
Aliases
Solid Comp
Solid Tumor NGS Panel
CPT
81455