Home
HelpTest Code LAB7988 Hematopoietic Neoplasms DNA Analysis
Special Collection Notes
Collect specimen according to standard operating procedure
Specimen Type
Whole Blood or Bone Marrow/Purple Top Tube (K2 EDTA). Tissue (Fresh Frozen, Paraffin Embedded (FFPE) or RPMI)
Processing Instructions
*Store and ship ambient. If transport is longer than 4 hours send refrigerated on cold pack.*For frozen tissue please send on dry ice- ASAP *Receipt within 24 hours of cutting or as soon as possible. Delays may impact nucleic acid quality.
Specimen Volume
Optimal Volume: 4.0 ml Minimum Volume: 0.5 ml Formalin-fixed, paraffin-embedded tissue block (preferred) or 10 micron unstained slides. (10 count).
Additional Notes
A paired non-tumor “normal” specimen may be submitted concurrently with the tumor specimen to allow for comparison and classification of variants as germline or somatic.
- Normal specimens may include blood or buccal swabs for solid tumors and fingernails for hematopoietic tumors.
- Normal specimens MUST be submitted at the same time as the tumor specimen to allow for paired analysis.
- Analysis of normal specimens is performed at no additional charge.
- The ordering clinician has the option to select for reporting of the germline/somatic status of variants at the time of tumor testing or to leave the status unreported until after review of variants identified in the tumor.
- The order for reporting of the germline/somatic status may be added at any time so long as the normal specimen was submitted at the same time as the tumor.
- The ordering clinician is responsible for obtaining patient consent for the reporting of germline variants.
TAT
21 days
Method
Next Generation Sequencing
CPT
81455
Performing Section
PRECISION DIAGNOSTICS
Purpose/Principle
This panel includes DNA analysis of 208 genes that have been described in the diagnosis, prognosis, or treatment decision process for a spectrum of lymphoid and myeloid.
Detection of single nucleotide variants (SNVs), small indels and flanking intronic regions in the following genes:
ABL1,ABL2,ALK,ANKRD26,ARID1A,ARID1B,ARID2,ASXL1,ASXL2,ATM,ATR,ATRX,B2M,BCL11B,BCL2,BCL6,BCOR,BCORL1, BRAF,BRCA1,BRCA2,BRIP1,BTK,CALR,CARD11,CBL,CBLB,CCND1,CCND2,CCND3,CCR4,CCR7,CD58,CD79A,CD79B,CDK4, CDK6,CDK8,CDKN1B,CDKN2A,CDKN2B,CDKN2C,CEBPA,CHEK1,CHEK2,CIC,CIITA,CREBBP,CRLF2,CSF1R,CSF3R, CTNNB1,CUX1,CXCL12,CXCR4,DDX3X,DDX41,DNM2,DNMT3A,EBF1,EED,EGFR,EP300,EPHA7,ERBB2,ERBB3,ERBB4,ERG, ESR1,ETV6,EZH2,FANCA,FANCC,FAS,FASLG,FBXW7,FGFR1,FGFR2,FGFR3,FGFR4,FLT3,FOXO1,FOXP1,GATA1,GATA2,GATA3, GLI1,GLI2,GNA13,HRAS,ID3,IDH1,IDH2,IGF1R,IKZF1,IKZF3,IL7R,INO80,JAK1,JAK2,JAK3,JUNB,KDM4C,KDM5A,KDM5C, KDM6A,KIR3DL2,KIT,KLF2,KMT2A,KMT2C,KMT2D,KRAS,MAP2K1,MAPK1,MDM2,MDM4,MECOM,MEF2B,MLH1,MPL,MSH2, MSH6,MTOR,MYC,MYCN,MYD88,NBN,NCOR2,NF1,NF2,NOP10,NOTCH1,NOTCH2,NPM1,NRAS,NT5C2,NTRK3,PAX5,PDGFRA, PDGFRB,PHF6,PIK3CA,PIK3R1,PIM1,PML,PMS2,PPM1D,PRDM1,PRPS1,PSMB5,PTCH1,PTEN,PTPN1,PTPN11,PTPRD,RAD21, RAD51,RAF1,RB1,REL,RELN,RET,RHOA,ROS1,RRAS,RUNX1,SAMD9,SAMD9L,SETBP1,SETD2,SF3B1,SGK1,SH2B3,SMARCA4, SMARCB1,SMC1A,SMC3,SMO,SOCS1,SRSF2,STAG2,STAT3,STAT5B,STAT6,SUZ12,TCF3,TENT5C,TERC,TERT,TET2,TET3, TLX1,TNFAIP3,TNFRSF10A,TNFRSF14,TP53,TP63,U2AF1,UBE2T,UBTF,USP7,WHSC1,WT1,XPO1,ZEB1,ZMYM3,ZRSR2