Purpose/Principle

This panel includes DNA analysis of 183 genes that have been described in the diagnosis, prognosis, or treatment decision process for a variety of solid tumors.  This panel was created with a focus on pediatric solid tumors but may be clinically relevant for a variety of adult neoplasms as well.

Detection of single nucleotide variants (SNVs), small indels and flanking intronic regions in the following genes:

ABL1,ACTB,ACTL6A,ACTL6B,AKT1,AKT2,AKT3,ALK,AMER1,APC,AR,ARAF,ARID1A,ARID1B,ARID2,ATM,ATR,ATRX,AURKA,AURKB, AXIN1,B2M,BCL2,BCL6,BCOR,BCORL1,BRAF,BRCA1,BRCA2,BRD4,BRIP1,CCND1,CCND2,CCND3,CD274,CDH1,CDK4,CDK6,CDKN1B, CDKN2A,CDKN2B,CDKN2C,CHEK2,CIC,CREBBP,CTNNB1,DAXX,DDR2,DDX3X,DICER1,DLG2,DPF1,DPF2,DPF3,DROSHA, EED,EGFR,EP300,ERBB2,ERBB3,ERG,ESR1,ETV6,EZH2,FGFR1,FGFR2,FGFR3,FGFR4,FH,FLCN,FUBP1,GLI2,GNA11,GNAQ,GNAS, GPC3,H3F3A,H3F3B,HIST1H1C,HIST1H3B,HRAS,IDH1,IDH2,IGF1R,IRS1,JAK1,JAK2,JAK3,JUN,KDM5A,KDM5C,KDM6A,KDR,KIT, KMT2A,KMT2C,KRAS,MAP2K1,MAP2K2,MAP2K4,MAP3K1,MAP3K3,MAPK1,MDM2,MDM4,MECOM,MEN1,MET,MLH1,MSH2,MSH6,MTOR, MYB,MYBL1,MYC,MYCN,MYOD1,NF1,NF2,NOTCH1,NOTCH2,NRAS,NTRK1,NTRK2,NTRK3,PAX5,PBRM1,PDCD1,PDGFRA,PDGFRB, PHF10,PHOX2B,PIK3CA,PIK3CB,PIK3CG,PIK3R1,PIK3R2,PMS2,POLD1,POLE,PPM1D,PTCH1,PTEN,PTPN11,PTPRD,RAF1,RB1,RET, RICTOR,ROS1,RPTOR,SDHA,SDHB,SDHC,SDHD,SETD2,SMAD2,SMAD4,SMARCA4,SMARCB1,SMARCC1,SMARCC2,SMARCD1,SMARCD2, SMARCD3,SMARCE1,SMO,SRC,STAG2,STAT3,STK11,SUFU,SUZ12,TERC,TERT,TGFBR2,TP53,TP63,TSC1,TSC2,VHL,WT1,XPO1