Home
HelpTest Code LAB7983 Neuro-Oncology DNA Analysis
Aliases
Somatic Testing
Special Collection Notes
Collect specimen according to standard operating procedure
Specimen Type
Whole Blood or Bone Marrow/Purple Top Tube (K2 EDTA). Tissue (Fresh Frozen, Paraffin Embedded (FFPE) or RPMI)
Processing Instructions
*Store and ship ambient. If transport is longer than 4 hours send refrigerated on cold pack.*For frozen tissue please send on dry ice- ASAP *Receipt within 24 hours of cutting or as soon as possible. Delays may impact nucleic acid quality.
Specimen Volume
Optimal Volume: 4.0 ml Minimum Volume: 0.5 ml Formalin-fixed, paraffin-embedded tissue block (preferred) or 10 micron unstained slides. (10 count).
Additional Notes
A paired non-tumor “normal” specimen may be submitted concurrently with the tumor specimen to allow for comparison and classification of variants as germline or somatic.
- Normal specimens may include blood or buccal swabs for solid tumors and fingernails for hematopoietic tumors.
- Normal specimens MUST be submitted at the same time as the tumor specimen to allow for paired analysis.
- Analysis of normal specimens is performed at no additional charge.
- The ordering clinician has the option to select for reporting of the germline/somatic status of variants at the time of tumor testing or to leave the status unreported until after review of variants identified in the tumor.
- The order for reporting of the germline/somatic status may be added at any time so long as the normal specimen was submitted at the same time as the tumor.
- The ordering clinician is responsible for obtaining patient consent for the reporting of germline variants.
TAT
21 days
Method
Next Generation Sequencing
CPT
81455
Performing Section
PRECISION DIAGNOSTICS
Purpose/Principle
This panel includes DNA analysis of 143 genes that have been described in the diagnosis, prognosis, or treatment decision process for central nervous system tumors
Detection of single nucleotide variants (SNVs), small indels and flanking intronic regions in the following genes:
ACTB, ACVR1, AKT1, AKT2, AKT3, ALK, APC, AR, ARID1A, ARID1B, ARID2, ATM, ATR, ATRX, AURKA, AURKB, BAP1, BCL2, BCL6, BCOR, BCORL1, BRAF, BRCA1, BRCA2, BRD4, CBL, CCND1, CCND2, CCND3, CD274, CDK4, CDK6, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CHEK2, CIC, CREBBP, CTNNB1, CYSLTR2, DAXX, DDX3X, DICER1, DNMT3A, DROSHA, EGFR, EPHA7, EZH2, FGFR1, FGFR2, FGFR3, FGFR4, FH, FUBP1, GLI1, GLI2, GNA11, GNAQ, GNAS, GPR161, H3F3A, H3F3B, HIST1H1C, HIST1H3B, HIST1H3C, IDH1, IDH2, IKBKAP, JAK2, JAK3, KBTBD4, KDM5A, KDM5C, KDM6A, KIT, KMT2A, KMT2C, KMT2D, KRAS, LZTR1, MAP2K1, MDM2, MDM4, MET, MLH1, MSH2, MSH6, MYB, MYBL1, MYC, MYCN, NF1, NF2, NOTCH1, NOTCH2, NRAS, NTRK1, NTRK2, NTRK3, PALB2, PDCD1, PDGFRA, PDGFRB, PIK3CA, PIK3CB, PIK3CG, PIK3R1, PIK3R2, PLAGL1, PLCB4, PMS2, POLE, POLR2A, PPM1D, PRKAR1A, PRKCA, PTCH1, PTEN, PTPN11, RB1, RET, SDHA, SDHB, SDHC, SDHD, SETD2, SMARCA4, SMARCB1, SMO, STAG2, STAT3, SUFU, TERC, TERT, TET2, TP53, TRAF7, TSC1, TSC2, VHL, WT1, ZMYM3