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Test Code LAB7982 RNA Fusion Analysis

Performing Section

PRECISION DIAGNOSTICS

Purpose/Principle

This panel includes genes that have been described as a partner in a fusion event in solid tumors, hematopoietic neoplasms, or both.

Special Collection Notes

Collect specimen according to standard operating procedure.

Specimen Type

Whole Blood/Bone Marrow : Purple Top Tube-EDTA

 

Mouth: Buccal Swab

 

Tissue (Fresh-Frozen, Paraffin Embedded, or RPMI)

Specimen Volume

Whole Blood/Bone Marrow

Preferred: 4.0 mL

Minimum: 0.5 mL

*Receipt of blood or bone marrow within 72 hours of collection. Delays may impact nucleic acid quality.

 

Tissue

Preferred: uncut paraffin-embedded tissue block. Slides: 1 stained and 10 unstained - 10 micron thick slides

*Receipt within 24 hours of cutting or as soon as possible. Delays may impact nucleic acid quality.

Processing Instructions

Store and ship ambient. If transport is longer than 4 hours send refrigerated on cold pack.
For frozen tissue please send on dry ice- ASAP.

Temperature

Ambient/Refrigerated

Test Components

Gene content:
ABI1, ABL1, ABL2, ACACA, ACE, ACER1, ACKR3, ACSL6, ACTB, ADD3, AFF1, AFF3, AFF4, AGR3, AHI1, AHRR, ALK, ANKRD28, AR, ARHGAP20, ARHGAP26, ARNT, ASPSCR1, ASTN2, ATF1, ATIC, ATP1B4, AUTS2, AXL, BACH2, BAG4, BAIAP2L1, BAZ2A, BCAS3, BCAS4, BCL10, BCL11A, BCL11B, BCL2, BCL2L1, BCL3, BCL6, BCL9, BCOR, BCR, BDNF, BICC1, BIRC3, BIRC6, BLNK, BRAF, BRD1, BRD3, BRD4, BRWD3, BTBD18, BTG1, C11orf1, C11orf95, C2CD2L, CAMTA1, CAPRIN1, CARS, CASC5, CASP7, CBFA2T3, CBFB, CBL, CCAR2, CCDC28A, CCDC6, CCDC88C, CCNB1IP1, CCNB3, CCND1, CCND2, CCND3, CD74, CDH11, CDK5RAP2, CDK6, CDX1, CDX2, CEBPA, CEBPB,CEBPD, CEBPE, CEP170B, CEP85L, CHD6, CHIC2, CHMP2B, CHST11, CIC, CIITA, CITED2, CLP1, CLTC, CLTCL1, CMKLR1, CNBP, CNOT2, CNTRL, COG5, COL1A1, COL1A2, COL6A3, COX6C, CPSF6, CRADD, CREB1, CREB3L1, CREB3L2, CREBBP, CRLF1, CRLF2, CRTC1, CSF1, CSF1R, CTDSP2, CTNNB1, CUX1, DAB2IP, DACH1, DACH2, DDIT3, DDX10, DDX20, DEK, DGKH, DMRT1, DNAJB1, DPM1, DUSP22, EBF1, EEFSEC, EGFR, EGR1, EGR2, EGR3, EGR4, EIF4A2, ELF4, ELK4, ELL, ELN, EML1, EML4, EP300, EP400, EPC1, EPOR, EPS15, ERBB2, ERBB3, ERC1, ERCC1, ERG, ERLIN2, ESR1, ETS1, ETV1, ETV4, ETV5, ETV6, EVL, EWSR1, EZR, FAM19A2, FCGR2B, FCRL4, FEN1, FEV, FGF8, FGFR1, FGFR1OP, FGFR1OP2, FGFR2, FGFR3, FGFR4, FGR, FHIT, FIP1L1, FLI1, FLNA, FLT3, FLT3LG, FNBP1, FOS, FOSB, FOSL1, FOXO1, FOXO4, FOXP1, FRK, FRYL, FUS, GAS7, GATA1, GIT2, GLI1, GLIS2, GOSR1, GOT1, GPR128, GPR34, GRHPR, GRID1, GRM1, GTF2I, H2AFX, HAS2, HEY1, HHEX, HIP1, HIPK1, HIST1H4I, HLF, HMGA2, HNF1A, HOXA10, HOXA11, HOXA13, HOXA9, HOXC11, HOXC13, HOXD11, HOXD13, HRAS, HSP90AA1, ID4, IKZF1, IKZF2, IKZF3, IL21R, IL2, IL2RB, IL3, INPP5D, INSR, IQCG, IRF2BP2, IRF4, IRS4, ITK, JAK1, JAK2, JAZF1, KANK1, KAT6A, KAT6B, KDM5A, KIAA1524, KIF5B, KMT2A, KMT2B, KMT2C, KMT2D, KPNB1, KRAS, KSR1, LASP1, LCK, LCP1, LGR5, LHFP, LHX2, LHX4, LMBRD1, LMO1, LMO2, LNP1, LPP, LPXN, LRMP, LRRC37B, LTBP1, LYL1, MACROD1, MAF, MAFB, MALT1, MAML2, MAN2B1, MAPRE1, MBNL1, MBTD1, MDS2, MEAF6, MECOM, MEF2D, MET, MGEA5, MLF1, MKL1, MKL2, MLLT1, MLLT10, MLLT11, MLLT3, MLLT4, MLLT6, MN1, MNX1, MSI2, MSN, MTCP1, MUC1, MUTYH, MYB, MYBL1, MYC, MYH11, MYH9, MYO18A, MYO1F, NAB2, NAPA, NBR1, NCOA1, NCOA2, NCOA3, NCOR1, NDE1, NF1, NFATC2, NFIB, NGF, NGFR, NIN, NIPBL, NKX2-1, NKX2-5, NONO, NOTCH1, NOTCH2, NPM1, NR4A3, NR6A1, NRAS, NRG1, NSD1, NT5C2, NTF3, NTF4, NTRK1, NTRK2, NTRK3, NUMA1, NUMBL, NUP107, NUP214, NUP98, NUTM1, NUTM2A, NUTM2B, OFD1, OLIG2, OLR1, OMD, P2RY8, PAPPA, PATZ1, PAX3, PAX5, PAX7, PAX8, PBX1, PCM1, PDE4DIP, PDGFB, PDGFRA, PDGFRB, PER1, PGR, PHF1, PHF23, PICALM, PIK3CA, PIM1, PKN1, PLAG1,PML, POM121, POU2AF1, POU5F1, PPAP2B, PPARG, PPARGC1A, PPFIBP1, PPP2R1B, PRCC, PRDM16, PRKACA, PRKAR1A, PRKCA, PRKCB, PRKG2, PRRX2, PSIP1, PSMD2, PTK2B, PTPRR, RABEP1, RAD51B, RAF1, RANBP2, RAP1GDS1, RARA, RBM15, RBM6, RCOR1, RCSD1, RELA, RET, RHOH, RNF213, ROS1, RPL22, RPN1, RREB1, RRM1, RSPO2, RSPO3, RTEL1, RUNX1, RUNX1T1, SARNP, SEC31A, SEPTIN2, SEPTIN5, SEPTIN6, SEPTIN9, SERPINE1, SERPINF1, SET, SETBP1, SFPQ, SH3D19, SH3GL1, SIK3, SLC34A2, SLC45A3, SLCO1B3, SMAP1, SMARCA5, SMARCB1, SNHG5, SORBS2, SORT1, SP3, SPECC1, SPTBN1, SQSTM1, SRF, SRSF3, SS18, SS18L1, SSBP2, SSX1, SSX2, SSX4, ST6GAL1, STAT5B, STAT6, STIL, STRN, SUFU, SUGP2, SUZ12, SYK, TACC1, TACC2, TACC3, TAF15, TAL1, TAL2, TAOK1, TBX15, TCF12, TCF3, TCL1A, TCTA, TEAD1, TEAD2, TEAD3, TEAD4, TEC, TENM1, TERT, TET1, TFE3, TFEB, TFG, TFPT, TFRC, TGFBR3, THADA, THRAP3, TIRAP, TLX1, TLX3, TMPRSS2, TNFRSF17, TOP1, TOP2B, TP53BP1, TP63, TP73, TPM3, TPM4, TRA, TRB, TRD, TRHDE, TRIM24, TRIP11, TRPS1, TSLP, TTYH1, TYK2, USP16, USP42,USP6, VGLL2, VGLL3, WASF2, WDR18, WDR70, WHSC1, WHSC1L1, WSB1, WT1, WWTR1, XIAP, YAP1, YTHDF2, YWHAE, ZBTB16, ZC3H7A, ZC3H7B, ZFP64, ZFPM2, ZFTA (c11orf95), ZFYVE19, ZMIZ1, ZMYM2, ZMYND11, ZNF207, ZNF384, ZNF444, ZNF521, ZNF585B, ZNF687

Reference Range

Result

No clinically significant variants identified

 

Variant(s)

This component has no reference ranges

TAT

21 days

Additional Notes

Not needed if also ordering comprehensive panel.

Aliases

RNA Fusion NGS Panel
Fusion

CPT

81456