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HelpTest Code LAB7757 Neutrophil Oxidative Burst
Aliases
DHR 123
DHR
NOB
Performing Section
Immunology/Flow
Specimen Type
Whole Blood:
Purple Top-EDTA (Preferred)
Dark Green Top-Sodium Heparin
Light Green Top-Lithium Heparin
Specimen Volume
Preferred: 3.0 mL
Minimum: 0.5 mL
Processing Instructions
Submit whole blood -DO NOT CENTRIFUGE.
Store and send ambient.
Sample must received into the lab Monday-Friday(before noon). Do not send sample on Friday (after noon), Saturday, Sunday or holidays.
TAT
24 hours
CPT
86352
Special Collection Notes
No Gel.
Mix sample well after collection to prevent specimen clotting.
Additional Notes
Testing must be performed within 24 hours.
Method
Flow Cytometry
Purpose/Principle
The Neutrophil Oxidative Burst (NOB) assay is used to support the diagnosis of X-linked Chronic Granulomatous Disease (XL-CGD), XL-CGD carriers, and autosomal recessive forms of CGD (AR-CGD). The NOB assay can also be used as a monitoring tool for success of engraftment following hematopoietic or stem cell transplant for CGD. The NOB assay is also useful for assessment of neutrophil function in patients with Glycogen Storage Disease type 1b (GSD-1b) pre- and post-therapy.
Temperature
Ambient
Sample Stability
Ambient: 24 hours
Test/Batch Schedule
Monday-Friday Noon
Test Components
NOB Result
Reference Range
Normal