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HelpTest Code LAB7448 Purines and Pyrimidines Panel, Random, Urine
Additional Codes
PUPYU
Useful For
Evaluating patients with symptoms suspicious for disorders of purine and pyrimidine metabolism
Monitoring patients with disorders of purine and pyrimidine metabolism
Laboratory evaluation of primary and secondary hyperuricemias
Method Name
Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)
Reporting Name
Purines and Pyrimidines Panel, USpecimen Type
UrineOrdering Guidance
This is recommended screening test for the initial workup of a suspected disorder of purine and pyrimidine metabolism, particularly when clinical features are nonspecific, and includes measurement of purines, pyrimidines, uric acid, and S-sulfocysteine. If the clinical features are suggestive of molybdenum cofactor deficiency, isolated sulfite oxidase deficiency, and hereditary xanthinuria, order SSCTU / S-Sulfocysteine Panel, Urine.
If this test is ordered with SSCTU, then SSCTU will be canceled.
Necessary Information
Patient's age is required.
Specimen Required
Supplies: Urine Tubes, 10 mL (T068)
Container/Tube: Plastic, 10-mL urine tube
Specimen Volume: 3 mL
Collection Instructions: Collect a random urine specimen.
Specimen Minimum Volume
2 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Urine | Frozen | 90 days |
Reject Due To
All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.Reference Values
|
Age range |
0-3 years |
4-6 years |
7-12 years |
13-18 years |
>18 years |
|
Uracil |
≤50 |
≤30 |
≤25 |
≤20 |
≤20 |
|
Thymine |
≤3 |
≤3 |
≤3 |
≤3 |
≤3 |
|
Adenine |
≤3 |
≤3 |
≤3 |
≤3 |
≤3 |
|
Hypoxanthine |
≤65 |
≤30 |
≤30 |
≤30 |
≤30 |
|
Xanthine |
≤54 |
≤21 |
≤35 |
≤15 |
≤20 |
|
Orotic |
≤4 |
≤4 |
≤3 |
≤3 |
≤5 |
|
Dihydroorotic acid |
≤3 |
≤3 |
≤3 |
≤3 |
≤3 |
|
Uric Acid |
350-2500 |
200-2000 |
200-1400 |
150-700 |
70-700 |
|
Deoxythymidine |
≤3 |
≤3 |
≤3 |
≤3 |
≤3 |
|
Deoxyuridine |
≤3 |
≤3 |
≤3 |
≤3 |
≤3 |
|
Thymidine |
≤3 |
≤3 |
≤3 |
≤3 |
≤3 |
|
Uridine |
≤10 |
≤3 |
≤3 |
≤3 |
≤3 |
|
Deoxyadenosine |
≤3 |
≤3 |
≤3 |
≤3 |
≤3 |
|
Deoxyinosine |
≤3 |
≤3 |
≤3 |
≤3 |
≤3 |
|
Deoxyguanosine |
≤3 |
≤3 |
≤3 |
≤3 |
≤3 |
|
Adenosine |
≤3 |
≤3 |
≤3 |
≤3 |
≤3 |
|
Inosine |
≤6 |
≤3 |
≤3 |
≤3 |
≤3 |
|
Guanosine |
≤4 |
≤3 |
≤3 |
≤3 |
≤3 |
|
5-Aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside (AICAR) |
≤3 |
≤3 |
≤3 |
≤3 |
≤3 |
|
Succinyladenosine |
≤16 |
≤3 |
≤3 |
≤3 |
≤3 |
|
S-Sulfocysteine |
≤11 |
≤5 |
≤5 |
≤5 |
≤5 |
|
Dihydrouracil |
≤15 |
≤6 |
≤6 |
≤6 |
≤6 |
|
Dihydrothymine |
≤11 |
≤3 |
≤3 |
≤3 |
≤3 |
|
N-Carbamoyl-B-alanine |
≤30 |
≤10 |
≤10 |
≤10 |
≤10 |
|
N-Carbamoyl-B-aminoisobutyric |
≤20 |
≤3 |
≤3 |
≤3 |
≤3 |
All results reported as mmol/mol creatinine
Day(s) Performed
Tuesday, Thursday
Report Available
3 to 7 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
CPT Code Information
82542
Forms
If not ordering electronically, complete, print, and send a Biochemical Genetics Test Request (T798) with the specimen.
Genetics Test Information
There are at least 35 known inherited disorders of purine and pyrimidine metabolism which cause a variety of neurological, immunological, hematological, and renal manifestations.