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Test Code LAB7433 t(9;22) BCR/ABL1 Analysis, Major Breakpoint by RT-PCR

Performing Section

PRECISION DIAGNOSTICS

Purpose/Principle

The GeneXpert BCR-ABL Monitor Ultra assay is an automated test for quantifying the amount of BCRABL1 fusion transcript as a ratio of BCR-ABL1/ABL1. The assay is performed on Cepheid GeneXpert Instrument Systems. The GeneXpert Instrument Systems automate and integrate sample purification, nucleic acid amplification, and target sequence detection in simple or complex samples using real-time RT-PCR and Nested PCR assays.

Special Collection Notes

Collect specimen according to standard operating procedure.

Specimen Type

Whole Blood/Bone Marrow : Purple Top Tube-EDTA

 

Mouth: Buccal Swab

 

Tissue (Fresh-Frozen, Paraffin Embedded, or RPMI)

Specimen Volume

Whole Blood/Bone Marrow Preferred: 4.0 mL Minimum: 0.5 mL **Receipt of blood or bone marrow within 72 hours of collection. Delays may impact nucleic acid quality.

 

Tissue: Preferred: uncut paraffin-embedded tissue block. Slides: 1 stained and 10 unstained - 10 micron thick slides *Receipt within 24 hours of cutting or as soon as possible. Delays may impact nucleic acid quality.

Processing Instructions

Store and ship ambient. If transport is longer than 4 hours send refrigerated on cold pack.
For frozen tissue please send on dry ice- ASAP.

Temperature

Ambient/Refrigerated

Test Components

t(9;22) BCR/ABL1, MAJOR BREAKPOINT DISCRETE RESULT
t(9;22) BCR/ABL1, MAJOR BREAKPOINT INTERNATIONAL SCALE
t (9;22) BCR/ABL1, ABL CT
t (9;22) BCR/ABL1, BCR-ABL CT
t(9;22) BCR/ABL1 IS Comment
t (9;22) BCR/ABL1, MR

Reference Range

T(9;22) BCR/ABL1, MAJOR BREAKPOINT DISCRETE RESULT

Not Detected

 

T(9;22) BCR/ABL1, MAJOR BREAKPOINT INTERNATIONAL SCALE

This component has no reference ranges set up

 

T (9;22) BCR/ABL1, ABL CT

<=16.0

 

T (9;22) BCR/ABL1, BCR-ABL CT

This component has no reference ranges

 

T (9;22) BCR/ABL1, MR

This component has no reference ranges

TAT

5 Days

Additional Notes

Specimen will be rejected if frozen or heparinized bone marrow or peripheral blood

Aliases

Major p210 Quant IS
Leukemia by RT-PCR

CPT

81206