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Test Code LAB7383 B Cell Gene Rearrangement Analysis, Diagnostic

Performing Section

PRECISION DIAGNOSTICS

Purpose/Principle

To identify and track B cell immunoglobulin heavy chain (IGH) gene rearrangements using Next-Generation Sequencing (NGS) using the Illumina MiSeq instrument and subsequent analysis using a custom bioinformatic pipeline.

Special Collection Notes

Collect specimen according to standard operating procedure.

Specimen Type

Whole Blood/Bone Marrow : Purple Top Tube-EDTA

 

Mouth: Buccal Swab

 

Tissue (Fresh-Frozen, Paraffin Embedded, or RPMI)

Specimen Volume

Whole Blood/Bone Marrow

Preferred: 4.0 mL

Minimum: 0.5 mL

*Receipt of blood or bone marrow within 72 hours of collection. Delays may impact nucleic acid quality.

 

Tissue

Preferred: uncut paraffin-embedded tissue block. Slides: 1 stained and 10 unstained - 10 micron thick slides

*Receipt within 24 hours of cutting or as soon as possible. Delays may impact nucleic acid quality.

Processing Instructions

Store and ship ambient. If transport is longer than 4 hours send refrigerated on cold pack.
For frozen tissue please send on dry ice- ASAP.

Temperature

Ambient/Refrigerated

Test Components

B Cell Result

Reference Range

Not Detected

TAT

11 days

Aliases

Diagnostic Ig Heavy Chain (IGH ) Gene Rearrangement

CPT

81261