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HelpTest Code LAB7381 B and T Cell Gene Rearrangement Analysis, Diagnostic
Performing Section
PRECISION DIAGNOSTICS
Purpose/Principle
To identify and track clonal T cell receptor gamma (TCRG) and B cell immunoglobulin heavy chain (IGH) gene rearrangements using Next-Generation Sequencing (NGS) using the Illumina MiSeq instrument and subsequent analysis using a custom bioinformatic pipeline.
Special Collection Notes
Collect specimen according to standard operating procedure.
Specimen Type
Whole Blood/Bone Marrow : Purple Top Tube-EDTAMouth: Buccal Swab
Tissue (Fresh-Frozen, Paraffin Embedded, or RPMI)
Specimen Volume
Whole Blood/Bone Marrow
Preferred: 4.0 mL
Minimum: 0.5 mL
*Receipt of blood or bone marrow within 72 hours of collection. Delays may impact nucleic acid quality.
Tissue
Preferred: uncut paraffin-embedded tissue block. Slides: 1 stained and 10 unstained - 10 micron thick slides
*Receipt within 24 hours of cutting or as soon as possible. Delays may impact nucleic acid quality.
Processing Instructions
Store and ship ambient. If transport is longer than 4 hours send refrigerated on cold pack.
For frozen tissue please send on dry ice- ASAP.
Temperature
Ambient/Refrigerated
Test Components
T Cell Result
B Cell Result
Reference Range
T Cell ResultNot Detected
B Cell Result
Not Detected
TAT
10 days
Aliases
Diagnostic TCRG and IGH Gene Rearrangement
CPT
81342
81261