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Test Code LAB10330 GDF15 and FGF21

Aliases

Growth Differentation Factor 15 and Firbroblast Growth Factor 21

Specimen Type

Serum/Plasma:

Light Green Top- Lithium Heparin (Preferred)

Red Top- Plain

Gold Top- SST

Dark Green Top- Sodium Heparin

Purple Top- EDTA

Processing Instructions

-Green, Gold, Purple Top – Centrifuge per procedure / Red Top – Clot 60 minutes in upright position -Pipette off plasma or serum into pour off tube -Attach original tube to pour off tube with rubber band -Place sample in freezer until courier arrives -Send sample frozen (on dry ice) overnight or via courier

Specimen Volume

Whole Blood
Optimal: 3.0mL (1.0 serum/plasma)
Minimum: 1.0 mL (0.3 serum/plasma)

Temperature

Frozen

TAT

14 Days

Test Components

GDF-15 Average
FGF-21 Average
Interpretation

Reference Range

GDF-15 Average

0 up to 7 Months:<=1946.0 ng/L

7 Months up to 18 Years: <=838.0 ng/L

18 Years up to 60 Years: <=1045.0 ng/L

60 Years up to 80 Years: <=2627 ng/L

 

FGF-21 Average

0 up to 7 Months: <=1550.0 ng/L

7 Months up to 9 Years: <=307.0 ng/L

9 Years up to 18 Years: <=454.0 ng/L

18 Years up to 80 years: <=887.0 ng/L

CPT

83520 x2

Performing Section

Mitochondrial Lab

Purpose/Principle

A circulating biomarker in myopathy-related mitochondrial disease as well as other conditions.

These markers may have other uses in pediatric medicine such as in heart failure, renal disease, and other liver disease.

Investigation of patients suspected of having a mitochondrial myopathy.

This assay is not suitable for carrier detection.

This test is not recommended for infants younger than 3 months of age due to the high levels of growth differentiation factor 15 contributed from the placenta during pregnancy.